Interspecies transmission of prions
Identifieur interne : 002548 ( Main/Exploration ); précédent : 002547; suivant : 002549Interspecies transmission of prions
Auteurs : E. G. Afanasieva [Russie] ; V. V. Kushnirov [Russie] ; M. D. Ter-Avanesyan [Russie]Source :
- Biochemistry (Moscow) [ 0006-2979 ] ; 2011-12-01.
English descriptors
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Abstract
Abstract: Mammalian prions are infectious agents of proteinaceous nature that cause several incurable neurodegenerative diseases. Interspecies transmission of prions is usually impeded or impossible. Barriers in prion transmission are caused by small interspecies differences in the primary structure of prion proteins. The barriers can also depend on the strain (variant) of a transmitted prion. Interspecies barriers were also shown for yeast prions, which define some heritable phenotypes. Yeast prions reproduce all the main traits of prion transmission barriers observed for mammals. This allowed to show that the barrier in prion transmission can be observed even upon copolymerization of two prionogenic proteins. Available data allow elucidation of the mechanisms that impede prion transmission or make it impossible.
Url:
DOI: 10.1134/S0006297911130013
Affiliations:
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Interspecies transmission of prions is usually impeded or impossible. Barriers in prion transmission are caused by small interspecies differences in the primary structure of prion proteins. The barriers can also depend on the strain (variant) of a transmitted prion. Interspecies barriers were also shown for yeast prions, which define some heritable phenotypes. Yeast prions reproduce all the main traits of prion transmission barriers observed for mammals. This allowed to show that the barrier in prion transmission can be observed even upon copolymerization of two prionogenic proteins. Available data allow elucidation of the mechanisms that impede prion transmission or make it impossible.</div></front></TEI><affiliations><list><country><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Afanasieva, E G" sort="Afanasieva, E G" uniqKey="Afanasieva E" first="E. G." last="Afanasieva">E. G. Afanasieva</name></region><name sortKey="Kushnirov, V V" sort="Kushnirov, V V" uniqKey="Kushnirov V" first="V. V." last="Kushnirov">V. V. Kushnirov</name><name sortKey="Ter Avanesyan, M D" sort="Ter Avanesyan, M D" uniqKey="Ter Avanesyan M" first="M. D." last="Ter-Avanesyan">M. D. Ter-Avanesyan</name><name sortKey="Ter Avanesyan, M D" sort="Ter Avanesyan, M D" uniqKey="Ter Avanesyan M" first="M. D." last="Ter-Avanesyan">M. D. Ter-Avanesyan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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